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The mismatch repair system is extra efficient. Which scenario is most likely true for these cells? Unexpectedly, a colony of cells continues to survive and divide past 30 generations. They can be maintained in culture but die off after about 30 cell generations. In some cells, an enzyme called _ repairs the shortened strand.Ī researcher studies normal human fibroblast cells. After successive rounds of DNA replication, the _ strand becomes shorter. In many eukaryotes, there are repetitive sequences called telomeres at the ends of chromosomes. Ligases and polymerases function in the vicinity of replication forks. Replication forks represent areas of active DNA synthesis on the chromosomes. The sliding clamp increases the rate of DNA synthesis. Okazaki fragments are synthesized as parts of the leading strand.Įrror rates for DNA replication are reduced by proofreading of the DNA polymerase. Which statement about DNA replication is false? Have two replication forks that move in the same direction. To replicate their DNA in a timely manner, most eukaryotic chromosomesĬontain linear molecules of single-stranded DNA. There would be no effect on DNA replication. Primase would not be able to provide primers for DNA polymerases.ĭNA polymerase would not be able to use DNA as a template. Primase would be blocked from joining the DNA replication complex. What effect would a primase inhibitor have on DNA replication?ĭNA polymerase would not be able to add bases to the DNA. High temperatures are required to denature it. Single-strand binding proteins are required to keep the strands apart. Which of the following does not demonstrate the stability of the DNA double helix? The DNA polymerase will only incorporate acyclovir molecules.Īcyclovir will bind single-strand binding proteins.ĭNA polymerase will not be able to link a successive nucleotide.Īcyclovir will block the activity of the DNA helicase. The replication complex will no longer bind to origins of replication. Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA. The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3â² hydroxyl group (âOH). If the MeselsonâStahl density gradient experiment had resulted in two bands of DNA molecules after only one round of replication, one containing only 15N and the second only 14N, this result would have indicated that replication was What structural aspect of the DNA facilitates dissociation of the two DNA strands for replication?Ĭovalent bonds between sugars and phosphate groups
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If a sequence of one strand of DNA is 5â²-TGACTATC-3â², what is the complementary strand? The uniform diameter of the DNA structure provides evidence for If 23 percent of the bases in a sample of double-stranded DNA are adenine, what percentage of the bases are uracil? In order to show that DNA in cell extracts is responsible for genetic transformation in Streptococcus pneumoniae, important corroborating evidence should indicate that _ also destroy transforming activity.īased on what you have learned about the experiments conducted by Griffith and Avery and colleagues with bacteria, which of the following would result in transformation of living R cells?Ī mixture of pure RNA and protein from S cellsįorm three hydrogen bonds with each other.Īre more heat-stable than G-C base pairs.Īre of a substantially different length than G-C base pairs.Īre not accessible to DNA binding proteins.Īre chemically distinct from G-C base pairs. In addition to identifying the genetic material, the experiments of Avery, MacLeod, and McCarty with different strains of Streptococcus pneumoniae demonstrated thatĭNA may be taken up by bacterial cells and be active.Įukaryotic cells may be genetically transformed.ĭNA binds to the cell wall of the bacterium.